References
1) Presence of mesenchymal stem cells in cord blood
Biebeck et al. 2004. Stem Cells 22:625-634
Ma et al 2012. Cell biology international (CBI20110173)
Murphy et al. 2013. Experimental and molecular medicine DOI 10.1038/emm.2013.94
2) Presence of hematopoietic stem cells in cord blood
Cord blood stem cell transplantation – www.lls.org
4) Presence of mesenchymal stem cells in cord tissue
5) Presence of unrestricted somatic stem cells (USSCs) in cord tissue
http://www.ncbi.nlm.nih.gov/pubmed/24460716
6) One million HSC transplants have been performed worldwide
http://www.bloodjournal.org/content/122/21/2133.full.pdf
7) 47% of privately banked cord blood releases have been used for regenerative therapies
Ballen et al. Bone Marrow Transplantation Umbilical cord blood donation: public or private 2015
8) Risk of rejection in unrelated cord blood transplantation
Bone Marrow Transplantation (2012) 47, 1186 — 1190
9) Characteristics of Graft versus host disease following a cord blood transplant
Bone Marrow Transplantation (2013) 48, 1285–1290
10) 1 in 3 individuals might benefit from a regenerative therapy
Harris DT, Badowski M, Ahmad N, Gaballa MA – Expert Opin Biol Ther. 2007 Sep 1311-22.
11) Over 30,000 cord blood transplants worldwide
http://www.nature.com/nbt/journal/v30/n4/full/nbt0412-304.html
12) Cord blood has been used in the treatment of over 80 diseases
Moise K Jr. Umbilical cord stem cells. Obstet Gynecol. 2005;106(6):1393-1407.
13) Stem cells have been used in over 6,500 clinical trials
https://clinicaltrials.gov/ct2/results?term=stem+cells&Search=Search
14) Hade MD, Suire CN, Suo Z. Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine. Cells. 2021;10(8):1959. [DOI](https://doi.org/10.3390/cells10081959) · PMID 34440728.
15) Zhou C, Zhang B, Yang Y, et al. Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing. Stem Cell Res Ther. 2023;14(1):107. [DOI](https://doi.org/10.1186/s13287-023-03345-0) · PMID 37101197.
16) Lotfy A, AboQuella NM, Wang H. Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials. Stem Cell Res Ther. 2023;14(1):66. [DOI](https://doi.org/10.1186/s13287-023-03287-7) · PMID 37024925.
17) Ha DH, Kim HK, Lee J, et al. Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration. Cells. 2020;9(5):1157. [DOI](https://doi.org/10.3390/cells9051157) · PMID 32392899.
18) Panda B, Sharma Y, Gupta S, Mohanty S. Mesenchymal Stem Cell-Derived Exosomes as an Emerging Paradigm for Regenerative Therapy and Nano-Medicine: A Comprehensive Review. Life (Basel). 2021;11(8):784. [DOI](https://doi.org/10.3390/life11080784) · PMID 34440528.
19) Liang Y, Duan L, Lu J, Xia J. Engineering exosomes for targeted drug delivery. Theranostics. 2021;11(7):3183-3195. [DOI](https://doi.org/10.7150/thno.52570) · PMID 33537081.
20) Yang J, Chen Z, Pan D, Li H, Shen J. Umbilical Cord-Derived Mesenchymal Stem Cell-Derived Exosomes Combined Pluronic F127 Hydrogel Promote Chronic Diabetic Wound Healing and Complete Skin Regeneration. Int J Nanomedicine. 2020;15:5911-5926. [DOI](https://doi.org/10.2147/IJN.S249129) · PMID 32848396.
21) Giovannelli L, Bari E, Jommi C, et al. Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: risk-benefit profile and next steps for market access. Bioact Mater. 2023;29:16-35. [DOI](https://doi.org/10.1016/j.bioactmat.2023.06.013) · PMID 37456581.
22) Zhou L, Liang J, Xiong T. Research progress of mesenchymal stem cell-derived exosomes on inflammatory response after ischemic stroke. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2022;51(4):500-506. [DOI](https://doi.org/10.3724/zdxbyxb-2022-0077) · PMID 37202091.
23) Pan Y, Wu W, Jiang X, Liu Y. Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: from mechanisms to therapy. Biomed Pharmacother. 2023;163:114817. [DOI](https://doi.org/10.1016/j.biopha.2023.114817) · PMID 37141733.
24) Zhao J, Li X, Hu J, et al. Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization. Cardiovasc Res. 2019;115(7):1205-1216. [DOI](https://doi.org/10.1093/cvr/cvz040) · PMID 30753344.
25) Cao H, Chen M, Cui X, et al. Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to Rejuvenate Aging Chondrocytes. ACS Nano. 2023;17(14):13358-13376. [DOI](https://doi.org/10.1021/acsnano.3c01612) · PMID 37439514.
26) He L, He T, Xing J, et al. Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis. Stem Cell Res Ther. 2020;11(1):276. [DOI](https://doi.org/10.1186/s13287-020-01781-w) · PMID 32650828.
27) Liu P, Yang S, Shao X, et al. Mesenchymal Stem Cells-Derived Exosomes Alleviate Acute Lung Injury by Inhibiting Alveolar Macrophage Pyroptosis. Stem Cells Transl Med. 2024;13(4):371-386. [DOI](https://doi.org/10.1093/stcltm/szad094) · PMID 38349749.
28) Huang D, Shen H, Xie F, et al. Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues. J Biol Eng. 2024;18(1):36. [DOI](https://doi.org/10.1186/s13036-024-00431-6) · PMID 38845032.
29) Beeraka NM, Doreswamy SH, Sadhu SP, et al. The role of exosomes in stemness and neurodegenerative diseases – chemoresistant-cancer therapeutics and phytochemicals. Int J Mol Sci. 2020;21(18):6818. [DOI](https://doi.org/10.3390/ijms21186818) · PMID 32957534.
